False positive reduction in protein-protein interaction predictions using gene ontology annotations
نویسندگان
چکیده
منابع مشابه
Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks
Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...
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A map of protein-protein interactions provides valuable insight into the cellular function and machinery of a proteome. By measuring the similarity between two Gene Ontology (GO) terms with a relative specificity semantic relation, here, we proposed a new method of reconstructing a yeast protein-protein interaction map that is solely based on the GO annotations. The method was validated using h...
متن کاملidentification and prioritization genes related to hypercholesterolemia qtls using gene ontology and protein interaction networks
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Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...
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Careful examination of the existing evidence underpins formulation of novel hypotheses and experimental design. However, each year the state of the ground truth becomes more difficult to approximate due to the rapid proliferation of primary literature and associated databases. With over a million new articles added to MEDLINE annually, mastering even the subfield literature has become difficult...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2007
ISSN: 1471-2105
DOI: 10.1186/1471-2105-8-262